Diabetes mellitus is associated with increased mortality and severity of disease in COVID-19 pneumonia – A systematic review, meta-analysis, and meta-regression

(چکیده مقاله) :
Abstract :

Background and Aims
Diabetes Mellitus (DM) is chronic conditions with devastating multi-systemic complication
and may be associated with severe form of Coronavirus Disease 2019 (COVID-19). We
conducted a systematic review and meta-analysis in order to investigate the association
between DM and poor outcome in patients with COVID-19 pneumonia.
Methods
Systematic literature search was performed from several electronic databases on subjects
that assess DM and outcome in COVID-19 pneumonia. The outcome of interest was
composite poor outcome, including mortality, severe COVID-19, acute respiratory distress
syndrome (ARDS), need for intensive care unit (ICU) care, and disease progression.
Results
There were a total of 6452 patients from 30 studies. Meta-analysis showed that DM was
associated with composite poor outcome (RR 2.38 [1.88, 3.03], p<0.001; I2: 62%) and its
subgroup which comprised of mortality (RR 2.12 [1.44, 3.11], p<0.001; I2: 72%), severe
COVID-19 (RR 2.45 [1.79, 3.35], p<0.001; I2: 45%), ARDS (RR 4.64 [1.86, 11.58], p=0.001; I2:
9%), and disease progression (RR 3.31 [1.08, 10.14], p=0.04; I2: 0%). Meta-regression
showed that the association with composite poor outcome was influenced by age (p=0.003)
and hypertension (p<0.001). Subgroup analysis showed that the association was weaker in
studies with median age ≥55 years-old (RR 1.92) compared to <55 years-old (RR 3.48),

(توضیحات تکمیلی) :

(توضیحات تکمیلی) :
Description :

مقاله ISI انگلیسی اصلی
سال انتشار: 2020
فایل ISI انگلیسی اصلی ، با فرمت Pdf
تعداد صفحات فایل ISI انگلیسی اصلی: 36 صفحه

Authors / Descriptions(نویسندگان/توضیحات): سال انتشار 2020 \ مقاله ISI انگلیسی اصلی \ نویسندگان: Ian Huang, Michael Anthonius Lim, Raymond Pranata
Sent date(تاریخ ارسال) : 1399/01/29  |   4/17/2020
Number of visits(تعداد بازدید): 1196
Key words (کلمات کلیدی): Coronavirus; COVID-19; Diabetes Mellitus; Mortality; SARS-CoV-2
Number of pages(تعداد صفحات) : 36
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