Can post-exposure prophylaxis for COVID-19 be considered as one of outbreak response strategies in long-term care hospitals?
(چکیده مقاله) :
Abstract :
With ongoing global outbreak of coronavirus disease 2019 (COVID-19), management of exposure
events is a concern. Long-term care hospitals (LTCHs) are especially vulnerable to cluster outbreaks,
since it is difficult to find facilities and healthcare personnel for their separate isolation care in a large
outbreak situation. Although several drugs have been proposed as treatment regimens, there are no
data on the effectiveness and safety of post-exposure prophylaxis (PEP) for COVID-19. After a large
COVID-19 exposure event in a LTCH in Korea, PEP using hydroxychloroquine (HCQ) was
conducted to 211 persons including 189 patients and 22 careworkers, whose baseline polymerase
chain reaction (PCR) tests for COVID-19 were negative. PEP was completed in 184 (97.4%) patients
and 21 (95.5%) careworkers without serious adverse events. At the end of 14 days of quarantine,
follow-up PCR tests were all negative. Based on our experience, further clinical studies would be
conducted for COVID-19 PEP.
events is a concern. Long-term care hospitals (LTCHs) are especially vulnerable to cluster outbreaks,
since it is difficult to find facilities and healthcare personnel for their separate isolation care in a large
outbreak situation. Although several drugs have been proposed as treatment regimens, there are no
data on the effectiveness and safety of post-exposure prophylaxis (PEP) for COVID-19. After a large
COVID-19 exposure event in a LTCH in Korea, PEP using hydroxychloroquine (HCQ) was
conducted to 211 persons including 189 patients and 22 careworkers, whose baseline polymerase
chain reaction (PCR) tests for COVID-19 were negative. PEP was completed in 184 (97.4%) patients
and 21 (95.5%) careworkers without serious adverse events. At the end of 14 days of quarantine,
follow-up PCR tests were all negative. Based on our experience, further clinical studies would be
conducted for COVID-19 PEP.
(توضیحات تکمیلی) :
(توضیحات تکمیلی) :
Description :
مقاله ISI انگلیسی اصلی
سال انتشار: 2020
فایل ISI انگلیسی اصلی ، با فرمت Pdf
تعداد صفحات فایل ISI انگلیسی اصلی: 12 صفحه
سال انتشار: 2020
فایل ISI انگلیسی اصلی ، با فرمت Pdf
تعداد صفحات فایل ISI انگلیسی اصلی: 12 صفحه
Authors / Descriptions(نویسندگان/توضیحات): سال انتشار 2020 \ مقاله ISI انگلیسی اصلی \ نویسندگان: Sun Hee Lee , Hyunjin Son , Kyong Ran Peck
Sent date(تاریخ ارسال) :
1399/01/29 | 4/17/2020
Number of visits(تعداد بازدید):
961
Key words (کلمات کلیدی):
Post-exposure prophylaxis; hydroxychloroquine; SARS-CoV-2; COVID-19; long-term care hospital
Number of pages(تعداد صفحات) :
12
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