Plasma IP-10 and MCP-3 levels are highly associated with disease severity and predict the progression of COVID-19
(چکیده مقاله) :
Abstract :
Background The outbreak of Coronavirus Disease 2019 (COVID-19) caused by the severe acute
respiratory syndrome coronavirus 2 (SARS-CoV-2) was first reported in Wuhan, December 2019, and
continuously poses a serious threat to public health, highlighting the urgent need of identifying
biomarkers for disease severity and progression.
Objective To identify biomarkers for disease severity and progression of COVID-19.
Methods Forty-eight cytokines in the plasma samples from 50 COVID-19 cases including 11 critically
ill, 25 severe and 14 moderate patients were measured and analyzed in combination with clinical data.
Results Fourteen cytokines were found to be significantly elevated in COVID-19 cases and showed
different expression profiles in patients with different disease severity. Moreover, expression levels of
IP-10, MCP-3, HGF, MIG and MIP-1α, which were shown to be highly associated with disease
severity during disease progression, were remarkably higher in critically ill patients, followed by severe
and then the moderate patients. Serial detection of the five cytokines in 16 cases showed that
continuously high levels were associated with deteriorated progression
respiratory syndrome coronavirus 2 (SARS-CoV-2) was first reported in Wuhan, December 2019, and
continuously poses a serious threat to public health, highlighting the urgent need of identifying
biomarkers for disease severity and progression.
Objective To identify biomarkers for disease severity and progression of COVID-19.
Methods Forty-eight cytokines in the plasma samples from 50 COVID-19 cases including 11 critically
ill, 25 severe and 14 moderate patients were measured and analyzed in combination with clinical data.
Results Fourteen cytokines were found to be significantly elevated in COVID-19 cases and showed
different expression profiles in patients with different disease severity. Moreover, expression levels of
IP-10, MCP-3, HGF, MIG and MIP-1α, which were shown to be highly associated with disease
severity during disease progression, were remarkably higher in critically ill patients, followed by severe
and then the moderate patients. Serial detection of the five cytokines in 16 cases showed that
continuously high levels were associated with deteriorated progression
(توضیحات تکمیلی) :
(توضیحات تکمیلی) :
Description :
مقاله ISI انگلیسی اصلی
سال انتشار: 2020
فایل ISI انگلیسی اصلی ، با فرمت Pdf
تعداد صفحات فایل ISI انگلیسی اصلی: 39 صفحه
سال انتشار: 2020
فایل ISI انگلیسی اصلی ، با فرمت Pdf
تعداد صفحات فایل ISI انگلیسی اصلی: 39 صفحه
Authors / Descriptions(نویسندگان/توضیحات): سال انتشار 2020 \ مقاله ISI انگلیسی اصلی \ نویسندگان: Yang Yang, MD, Chenguang Shen, PhD, Jinxiu Li, MD, Jing Yuan, MD, Jinli Wei, MM, Fengmin Huang, MD, Fuxiang Wang, MD, Guobao Li, MD, Yanjie Li, MM, Li Xing, MM, Ling Peng, MM, Minghui Yang, PhD, Mengli Cao, MM, Haixia Zheng, MM, Weibo Wu, MM, Rongrong Zou, MD, Delin Li, PhD, Zhixiang Xu, MM, Haiyan Wang, PhD, Mingxia Zhang, MM, Zheng Zhang, MD, George F. Gao, DPhil, Chengyu Jiang, PhD, Lei Liu, MD, Yingxia Liu, MD
Sent date(تاریخ ارسال) :
1399/02/11 | 4/30/2020
Number of visits(تعداد بازدید):
846
Key words (کلمات کلیدی):
COVID-19; SARS-CoV-2; biomarkers; disease progression; prediction
Number of pages(تعداد صفحات) :
39
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